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N,N,N',N'-Tetramethylazodicarboxamide → {5-[5-(4-Trifluoromethoxy-phenyl)-pent-4-ynyloxy]-indol-1-yl}-acetic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N,N,N',N'-Tetramethylazodicarboxamide | HCID 4278 | — |
| 反応物 | Tributylphosphine | HCID 13831 | — |
| 反応物 | (5-Hydroxy-indol-1-yl)-acetic acid ethyl ester | HCID 57675474 | — |
| 反応物 | 4-Pentyn-1-ol, 5-[4-(trifluoromethoxy)phenyl]- | HCID 68822690 | — |
| 生成物 | {5-[5-(4-Trifluoromethoxy-phenyl)-pent-4-ynyloxy]-indol-1-yl}-acetic acid ethyl ester | HCID 68822255 | — |
反応手順
In analogy to the procedure described for example 1 d], (5-hydroxy-indol-1-yl)-acetic acid ethyl ester was reacted with 5-(4-trifluoromethoxy-phenyl)-pent-4-yn-1-ol in the presence of N,N,N′,N′-tetramethyl azodicarboxamide and tributylphosphine to give the title compound as yellow crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07405236B2 |
| 出典データセット | uspto-grants-2008_07 |
| ORD ID | ord-85837d0d6230447ab8156956a11dcf0e |
| 出典メモ | uspto-grants-2008_07 |