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Potassium Iodide → [rac]-2-{6-[5-(4-Trifluoromethoxy-phenyl)-pent-4-ynyloxy]-indol-1-yl]-propionic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Iodide | HCID 4875 | — |
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | Methanesulfonic acid 5-(4-trifluoromethoxy-phenyl)-pent-4-ynyl ester | HCID 11616756 | — |
| 反応物 | [Rac]-2-(6-hydroxy-indol-1-yl)-propionic acid ethyl ester | HCID 68826438 | — |
| 生成物 | [rac]-2-{6-[5-(4-Trifluoromethoxy-phenyl)-pent-4-ynyloxy]-indol-1-yl]-propionic acid ethyl ester | HCID 68824015 | — |
反応手順
In analogy to the procedure described in example 11 c], [rac]-2-(6-hydroxy-indol-1-yl)-propionic acid ethyl ester (GB 2253848 A1) was reacted with methanesulfonic acid 5-(4-trifluoromethoxy-phenyl)-pent-4-ynyl ester (example 9 a]) in the presence of cesium carbonate and potassium iodide to give the title compound as colorless liquid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07405236B2 |
| 出典データセット | uspto-grants-2008_07 |
| ORD ID | ord-244fb64dfeee4a8aa06781a10a19884e |
| 出典メモ | uspto-grants-2008_07 |