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1-Iodo-4-(trifluoromethoxy)benzene → 2-(1H-Indol-6-yl)-N-[3-(4-trifluoromethoxy-phenyl)-prop-2-ynyl]-acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Iodo-4-(trifluoromethoxy)benzene | HCID 2777294 | — |
| 反応物 | 2-(1H-Indol-6-yl)-N-prop-2-ynyl-acetamide | HCID 86095505 | — |
| 生成物 | 2-(1H-Indol-6-yl)-N-[3-(4-trifluoromethoxy-phenyl)-prop-2-ynyl]-acetamide | HCID 68825664 | — |
反応手順
In analogy to the procedure described for example 8 a], 2-(1H-indol-6-yl)-N-prop-2-ynyl-acetamide was reacted with 4-(trifluoromethoxy)-iodobenzene in the presence of PdCl2(Ph3P)2 and cuprous iodide to give the title compound as colorless crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07405236B2 |
| 出典データセット | uspto-grants-2008_07 |
| ORD ID | ord-2d278a71bb944401bfba164c31f4be3d |
| 出典メモ | uspto-grants-2008_07 |