関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 1-Phenylisatin | HCID 12884 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 溶媒 | Ethylene Glycol | HCID 174 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 1-Phenyloxindole | HCID 314787 | 90% |
反応手順
To a solution of commercially available 1-phenyl-1H-indole-2,3-dione (10.10 g, 45.7 mmol) in ethylene glycol (125 mL) is added powdered potassium hydroxide (7.4 g, 112 mmol), hydrazine hydrate (16.35 mL) and water (4 mL). The reaction is heated to 160° C. for 1.5 hr after which it is cooled to room temperature, made acidic with conc. hydrochloric acid, diluted with water and the resulting solids are collected by filtration. The solid is washed with water, dissolved in dichloromethane, dried and the solvent removed to give the 1-phenyl-1H-indol-2-one (8.6 g, 90% yield) as a solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07405300B2 |
|---|
| 出典データセット | uspto-grants-2008_07 |
|---|
| ORD ID | ord-3db108bdf9ab4cf4acff58245c1627ce |
|---|
| 出典メモ | uspto-grants-2008_07 |
|---|
