Water → 3-(Cyanomethyl)pyridin-1-ium-1-olate

HRID 751350ノート

反応式

HRID 751350 の反応式
C(OO)(=[O:3])C.[N:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:12][C:13]#[N:14])[CH:7]=1.O>C(O)(=O)C>[CH:10]1[CH:11]=[N+:6]([O-:3])[CH:7]=[C:8]([CH2:12][C:13]#[N:14])[CH:9]=1

参加物

5

反応物 3

HCID 962WaterHCID 6585Peracetic AcidHCID 809233-Pyridineacetonitrile

生成物 1

HCID 2431673-(Cyanomethyl)pyridin-1-ium-1-olate

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
95 °C

実験手順

The title compound is prepared in accordance with the procedures as outlined in S. Okuda et al., J. Am. Chem. Soc., 81, 740, (1959). Peracetic acid (38%, 40 mL, 0.2 mol) is added to a stirred solution of 3-pyridylacetonitrile (15.0 g, 127 mmol) in acetic acid (75 mL) and the reaction is heated at 95° C. for 24 hr, then stirred at room temperature for 24 hr. Water is added and the solvents are removed. More water (100 mL) is added and again removed. This process is repeated with toluene and with ether to give (1-oxypyridin-3-yl)acetonitrile as a cream solid.

後処理

  1. customThe title compound is prepared in accordance with the procedures
  2. customthe solvents are removed
  3. additionMore water (100 mL) is added
  4. customagain removed

出典と根拠

ORDレコード
ord-735dcf326d3e463d8f672432138e8564
出典データセット
uspto-grants-2008_07
特許番号
US07405300B2

反応ノート

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