Hydrochloric Acid → N-methyloxan-4-amine hydrochloride
反応式
C([CH2:8][NH:9][CH:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1)C1C=CC=CC=1.[ClH:16]>CO.CCOCC>[ClH:16].[CH3:8][NH:9][CH:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1参加物
5
実験手順
The title compound was prepared according to Preparation 23 from benzylmethyl(tetrahydropyran-4-yl)amine (Preparation 87). Crude material was dissolved in methanol and a solution of 1M HCl in ether was added dropwise to form a precipitate. The product was filtered and washed with ether to give the title compound as the hydrochloride salt as a white crystalline solid. δH (CD3OD): 4.11–4.00 (2H, m), 3.53–3.43 (2H, m), 3.37–3.27 (11H, m), 2.74 (3H, s), 2.11–2.03 (2H, m), 1.74–1.60 (2H, m).
後処理
- customThe title compound was prepared
- customto form a precipitate
- filtrationThe product was filtered
- washwashed with ether
出典と根拠
- ORDレコード
- ord-5944af5a146246bc9714eec04556c1a2
- 出典データセット
- uspto-grants-2008_07
- 特許番号
- US07405210B2
反応ノート
読み込み中…