Hydrochloric Acid → [(S)-1-((S)-1-Benzyloxycarbonyl-ethylcarbamoyl)-ethyl]-methyl-ammonium Chloride

HRID 751752ノート

反応式

HRID 751752 の反応式
C(O[C:6]([N:8](C)[C@@H:9]([CH3:25])[C:10]([NH:12][C@@H:13]([CH3:24])[C:14]([O:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:15])=[O:11])=O)(C)(C)C.[ClH:27]>O1CCOCC1>[Cl-:27].[CH2:17]([O:16][C:14]([C@@H:13]([NH:12][C:10]([C@@H:9]([NH2+:8][CH3:6])[CH3:25])=[O:11])[CH3:24])=[O:15])[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 14673102Benzyl (S)-2-[(S)-2-(tert-butoxycarbonyl-methyl-amino)-propanoylamino]-propionate

生成物 1

HCID 86598028[(S)-1-((S)-1-Benzyloxycarbonyl-ethylcarbamoyl)-ethyl]-methyl-ammonium Chloride

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

7.80 g (21.4 mmol) of the compound from example 4A are dissolved in 4N hydrogen chloride solution in dioxane (80 ml). After a few minutes, precipitate formation commences. The mixture is stirred for a further 1 h at RT, and the solid is filtered off with suction and washed with diethyl ether. After drying in vacuo, 5.96 g (93% of th.) of the product are obtained.

後処理

  1. waitAfter a few minutes
  2. filtrationthe solid is filtered off with suction
  3. washwashed with diethyl ether
  4. customAfter drying in vacuo, 5.96 g (93% of th.) of the product
  5. customare obtained

出典と根拠

ORDレコード
ord-f0892764b7444631a9c629c880ad8901
出典データセット
uspto-grants-2008_07
特許番号
US07405201B2

反応ノート

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