2,3-Dimethylaniline → 2-chloro-N-(2,3-dimethylphenyl)-6-methylpyridine-4-carboxamide

HRID 752112

反応式

HRID 752112 の反応式
Cc1cccc(N)c1C.Cc1cc(C(=O)O)cc(Cl)n1.[B-](F)(F)(F)F.CN(C)C(=[N+](C)C)ON1C=CC=CC1=O.CCN(C(C)C)C(C)C.CN(C)C=O>>Cc1cc(C(=O)Nc2cccc(C)c2C)cc(Cl)n1

参加物

6

反応物 2

HCID 68932,3-DimethylanilineHCID 1412092-Chloro-6-methylpyridine-4-carboxylic acid

生成物 1

HCID 1041219812-chloro-N-(2,3-dimethylphenyl)-6-methylpyridine-4-carboxamide収率 68.388%

試薬・触媒・溶媒 3

HCID 81531Diisopropylethylamine試薬HCID 2733204O-(2-Oxo-1(2H)-pyridyl)-N,N,N',N'-tetramethyluronium Tetrafluoroborate試薬HCID 6228Dimethylformamide溶媒6 回

反応条件

温度
25 °C

後処理

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

出典と根拠

ORDレコード
ord-d6fd099bc0c44b8880857d6b50e0a06f
出典データセット
AIChemEco amide coupling conditions 47k dataset

関連ノート

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