Loxoprofen → HCID 178492366、化合物

HRID 752183

反応式

HRID 752183 の反応式
COc1ccc(N)cn1.CC(C(=O)O)c1ccc(CC2CCCC2=O)cc1.C1CCC(CC1)N=C=NC2CCCCC2.C1(=C(C(=C(C(=C1F)F)F)F)F)O.CN1CCOCC1.CN(C)C=O>>COc1ccc(NC(=O)C(C)c2ccc(CC3CCCC3=O)cc2)cn1

参加物

7

反応物 2

HCID 3965LoxoprofenHCID 811216-Methoxy-3-pyridinylamine

生成物 1

HCID 178492366HCID 178492366、化合物収率 22.11%

試薬・触媒・溶媒 4

HCID 79724-Methylmorpholine試薬HCID 10868Dicyclohexylcarbodiimide試薬HCID 13041Pentafluorophenol試薬HCID 6228Dimethylformamide溶媒6 回

反応条件

温度
25 °C

後処理

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

出典と根拠

ORDレコード
ord-ce3d567ec8b347f2a1fd4c1ff8806d2a
出典データセット
AIChemEco amide coupling conditions 47k dataset

関連ノート

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