化工社化工社 化学情報印刷レポート · 研究参考用
Benzodiazepine → N-methylbenzodiazepine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzodiazepine | HCID 134664 | — |
| 反応物 | Methyl iodide sodium hydride | HCID 23686416 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 生成物 | N-methylbenzodiazepine | HCID 12543525 | — |
反応手順
The bromide 20 available from references 9 and 10 was reacted with trimethylsilyacetylene in the presence of a palladium catalyst to provide trimethylsilyl analog 52. This product was methylated with methyl iodide/sodium hydride to give the N-methyl benzodiazepine 54 (XLi 351). This was subjected to fluoride-mediated desilation to furnish 53 (XLi 350) and 55 (XLi 352).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08835424B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-1b3beb3ba5df4868b8f6774c959dce1a |
| 出典メモ | uspto-grants-2014_09 |