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Phenylacetonitrile → 2-Amino-5-iodobenzophenone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phenylacetonitrile | HCID 8794 | — |
| 反応物 | 1-Iodo-4-nitrobenzene | HCID 12495 | — |
| 反応物 | 2-Amino-5-chlorobenzophenone | HCID 12870 | — |
| 反応物 | Diethyl chlorophosphate | HCID 13139 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | Benzodiazepine | HCID 134664 | — |
| 反応物 | Ethyl isocyanoacetate | HCID 533707 | — |
| 生成物 | 2-Amino-5-iodobenzophenone | HCID 12906640 | — |
反応手順
2-Amino-5-iodo-benzophenone was prepared from p-iodonitrobenzene and phenylacetonitrile according to the literature. 2-Amino-5-chloro-benzophenone was commercially available from Acros. The benzodiazepine 60 was reacted with diethylphosphorochloridate in the presence of sodium hydride, followed by the addition of ethyl isocyanoacetate to provide the ester 62 (Hz120), as shown in Scheme 13.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08835424B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-f1662cbb6fb246f4be0376cb71edfe68 |
| 出典メモ | uspto-grants-2014_09 |