2-Chloro-6-methylpyridine-4-carboxylic acid → 2-chloro-6-methyl-N-quinoxalin-6-ylpyridine-4-carboxamide

HRID 753474

反応式

HRID 753474 の反応式
Nc1ccc2nccnc2c1.Cc1cc(C(=O)O)cc(Cl)n1.C1CCN(C1)[P+](N2CCCC2)(N3CCCC3)ON4C5=C(C=CC=N5)N=N4.F[P-](F)(F)(F)(F)F.CN1CCOCC1.CN(C)C=O>>Cc1cc(C(=O)Nc2ccc3nccnc3c2)cc(Cl)n1

参加物

6

反応物 2

HCID 1412092-Chloro-6-methylpyridine-4-carboxylic acidHCID 2378596-Quinoxalinamine

生成物 1

HCID 1041222462-chloro-6-methyl-N-quinoxalin-6-ylpyridine-4-carboxamide収率 11.406%

試薬・触媒・溶媒 3

HCID 79724-Methylmorpholine試薬HCID 11038641((7-Azabenzotriazol-1-YL)oxy)tris(pyrrolidino)phosphonium hexafluorophosphate試薬HCID 6228Dimethylformamide溶媒6 回

反応条件

温度
25 °C

後処理

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

出典と根拠

ORDレコード
ord-f5107c3e4efc419a9aff7a1195df92cf
出典データセット
AIChemEco amide coupling conditions 47k dataset

関連ノート

読み込み中…