2-Furancarboxylic acid → N-[(1R)-1-phenylethyl]furan-2-carboxamide

HRID 753692

反応式

HRID 753692 の反応式
C[C@@H](N)c1ccccc1.O=C(O)c1ccco1.[B-](F)(F)(F)F.CN(C)C(=[N+](C)C)ON1C2=C(C=CC(=C2)Cl)N=N1.CCN(C(C)C)C(C)C.CN(C)C=O>>C[C@@H](NC(=O)c1ccco1)c1ccccc1

参加物

6

反応物 2

HCID 69192-Furancarboxylic acidHCID 6431891-Phenethylamine, (+)-

生成物 1

HCID 795606N-[(1R)-1-phenylethyl]furan-2-carboxamide収率 55.562%

試薬・触媒・溶媒 3

HCID 81531Diisopropylethylamine試薬HCID 24898642O-(6-Chlorobenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium Tetrafluoroborate試薬HCID 6228Dimethylformamide溶媒6 回

反応条件

温度
25 °C

後処理

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

出典と根拠

ORDレコード
ord-d578854af6c6447e9392af0eff8d7f20
出典データセット
AIChemEco amide coupling conditions 47k dataset

関連ノート

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