化工社化工社 化学情報印刷レポート · 研究参考用
2-Propanol, 1-amino-2-methyl- → Methyl 2-(4-chlorophenyl)-3-(2-hydroxy-2-methylpropylamino)propanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Propanol, 1-amino-2-methyl- | HCID 95102 | — |
| 反応物 | Methyl 2-(4-chlorophenyl)acrylate | HCID 11735736 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | Methyl 2-(4-chlorophenyl)-3-(2-hydroxy-2-methylpropylamino)propanoate | HCID 68627364 | 100.4% |
反応手順
1-Amino-2-methyl-propan-2-ol (0.408 g, 4.58 mmol) was added to a solution of methyl 2-(4-chlorophenyl)acrylate (0.300 g, 1.52 mmol) in tetrahydrofuran (3.84 mL). The reaction was allowed to stir at room temperature overnight and produced crude methyl 2-(4-chlorophenyl)-3-(2-hydroxy-2-methylpropylamino)propanoate (436 mg, 100%). LCMS: M+1 286.5.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08835434B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-8540affbea47465aa01b8fb0617ffe81 |
| 出典メモ | uspto-grants-2014_09 |