Cyclopentanecarbonyl chloride → N-[1-(3-cyclopropyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propyl]cyclopentanecarboxamide

HRID 7542

反応式

HRID 7542 の反応式
[NH2:1][CH:2]([C:5]1[C:6](=[O:14])[NH:7][C:8]([CH:11]2[CH2:13][CH2:12]2)=[N:9][N:10]=1)[CH2:3][CH3:4].[CH:15]1([C:20](Cl)=[O:21])[CH2:19][CH2:18][CH2:17][CH2:16]1>>[CH:11]1([C:8]2[NH:7][C:6](=[O:14])[C:5]([CH:2]([NH:1][C:20]([CH:15]3[CH2:19][CH2:18][CH2:17][CH2:16]3)=[O:21])[CH2:3][CH3:4])=[N:10][N:9]=2)[CH2:13][CH2:12]1

参加物

3

反応物 2

HCID 78284Cyclopentanecarbonyl chlorideHCID 1355940716-(1-Aminopropyl)-3-cyclopropyl-1,2,4-triazin-5(4h)-one

生成物 1

HCID 135752607N-[1-(3-cyclopropyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propyl]cyclopentanecarboxamide

実験手順

In analogy to the procedure for Example 36A, 250 mg (1.29 mmol) 6-(1-aminopropyl)-3-cyclopropyl-1,2,4-triazin-5(4H)-one, 170 mg (1.29 mmol) cyclopentanecarbonyl chloride and proportionate amounts of the other reagents are used. The crude product is used in the next step without further purification.

後処理

  1. customThe crude product is used in the next step without further purification

出典と根拠

ORDレコード
ord-6913902c0d744d708d3052c48a047039
出典データセット
uspto-grants-2006_08
特許番号
US07087605B2

関連ノート

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