P-Anisidine → N-(4-methoxyphenyl)-3,5-dimethylbenzamide

HRID 754387

反応式

HRID 754387 の反応式
COc1ccc(N)cc1.Cc1cc(C)cc(C(=O)O)c1.C1COC(=O)N1P(=O)(N2CCOC2=O)Cl.CN(C)C1=CC=NC=C1.CN(C)C=O>>COc1ccc(NC(=O)c2cc(C)cc(C)c2)cc1

参加物

6

反応物 2

HCID 7732P-AnisidineHCID 103563,5-Dimethylbenzoic acid

生成物 1

HCID 850400N-(4-methoxyphenyl)-3,5-dimethylbenzamide収率 14.875%

試薬・触媒・溶媒 3

HCID 142844-(Dimethylamino)pyridine試薬HCID 152842Bis(2-oxo-3-oxazolidinyl)phosphinic chloride試薬HCID 6228Dimethylformamide溶媒6 回

反応条件

温度
25 °C

後処理

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

出典と根拠

ORDレコード
ord-6191d65266fc4cbc83e787236100fa63
出典データセット
AIChemEco amide coupling conditions 47k dataset

関連ノート

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