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Ethanol → (E)-ethyl 2-acetamido-3-(dimethylamino)but-2-enoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | (E)-4-(1-(dimethylamino)ethylidene)-2-methyloxazol-5(4H)-one | HCID 21985397 | — |
| 生成物 | (E)-ethyl 2-acetamido-3-(dimethylamino)but-2-enoate | HCID 54579441 | — |
反応手順
4-[1-dimethylamino-eth-(Z)-ylidene]-2-methyl-4H-oxazole-5-one (compound 15, 7.54 g, 44.8 mmol) was dissolved in ethanol (50 mL) and sodium hydride (179 mg, 4.5 mmol, 60% dispersion in mineral oil) wad added at room temperature. The solution was refluxed for 1 hr. The solvent was evaporated and the crude product was used without any further purification for the next step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08835436B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-05e04b54a61043f28d14b22210ba2a75 |
| 出典メモ | uspto-grants-2014_09 |