関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hexamethyldisilazane | HCID 13838 | — |
| 反応物 | Ammonium Sulfate | HCID 6097028 | — |
| 反応物 | (E)-Ethyl 2-acetamido-3-(cyclopentylamino)but-2-enoate | HCID 54579442 | — |
| 生成物 | Ethyl 1-cyclopentyl-2,5-dimethyl-1H-imidazole-4-carboxylate | HCID 54579443 | 71.7% |
反応手順
Ammonium sulfate (100 mg) was added to a solution of (E)-ethyl 2-acetamido-3-(cyclopentylamino)but-2-enoate (compound 18, 1.5 g, 5.9 mmol) and hexamethyldisilazane (15 mL) and refluxed overnight at 150° C. The reaction mixture was evaporated and extracted with EA and water. The organic layer was evaporated and the residue was purified with 20% methanol in CH2Cl2 to produce as a light brown solid (1.0 g, 71.4% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08835436B2 |
|---|
| 出典データセット | uspto-grants-2014_09 |
|---|
| ORD ID | ord-d60c4c69e8b14d838b11d92221ff0a9b |
|---|
| 出典メモ | uspto-grants-2014_09 |
|---|
