Diethyl Ether → HCID 178496014、化合物

HRID 75530ノート

反応式

HRID 75530 の反応式
[NH2:1][C:2]([NH:6][C@@H:7]1[CH2:12][CH2:11][CH2:10][CH2:9][C@@H:8]1[NH:13][C:14]1[C:23]2[C:18](=[CH:19][CH:20]=[C:21]([CH3:24])[CH:22]=2)[N:17]=[C:16]([C:25]([NH:27][CH2:28][CH2:29][O:30][CH3:31])=[O:26])[N:15]=1)=[N:3][O:4][CH3:5].C(OCC)(=O)C.[ClH:38].C(OCC)C>C(OCC)(=O)C>[ClH:38].[ClH:38].[NH2:1][C:2]([NH:6][C@@H:7]1[CH2:12][CH2:11][CH2:10][CH2:9][C@@H:8]1[NH:13][C:14]1[C:23]2[C:18](=[CH:19][CH:20]=[C:21]([CH3:24])[CH:22]=2)[N:17]=[C:16]([C:25]([NH:27][CH2:28][CH2:29][O:30][CH3:31])=[O:26])[N:15]=1)=[N:3][O:4][CH3:5]

参加物

5

反応物 3

HCID 3283Diethyl EtherHCID 21866389Hydrogen chloride-ethyl acetateHCID 178496013HCID 178496013、化合物

生成物 1

HCID 178496014HCID 178496014、化合物

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

1.71 g of 4-[((1S,2R)-2-{[amino(methoxyimino)methyl]amino}cyclohexyl)amino]-N-(2-methoxyethyl)-6-methyl quinazolin-2-carboxamide was suspended in 20 ml of ethyl acetate, and 5 ml of a 4 N hydrogen chloride-ethyl acetate solution was added thereto, and the mixture was stirred for 15 minutes. To the reaction solution, 40 ml of diethyl ether was added, and the resulting deposited substance was collected by filtration, washed with diethyl ether and dried under reduced pressure, whereby 2.01 g of a desired compound was obtained as a white powder.

後処理

  1. filtrationwas collected by filtration
  2. washwashed with diethyl ether
  3. customdried under reduced pressure

出典と根拠

ORDレコード
ord-f3deb738906c452eb67f70233e81891a
出典データセット
uspto-grants-2014_09
特許番号
US08835446B2

反応ノート

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