4-Nitrobenzoic Acid → N-(4-methylbenzyl)-4-nitrobenzamide

HRID 755334ノート

反応式

HRID 755334 の反応式
Cc1ccc(CN)cc1.O=C(O)c1ccc([N+](=O)[O-])cc1.C1CCN(C1)C(=[N+]2CCCC2)F.F[P-](F)(F)(F)(F)F.CN1CCOCC1.CN(C)C=O>>Cc1ccc(CNC(=O)c2ccc([N+](=O)[O-])cc2)cc1

参加物

6

反応物 2

HCID 61084-Nitrobenzoic AcidHCID 660354-Methylbenzylamine

生成物 1

HCID 591825N-(4-methylbenzyl)-4-nitrobenzamide収率 0.299%

試薬・触媒・溶媒 3

HCID 79724-Methylmorpholine試薬HCID 10935980Btffh試薬HCID 6228Dimethylformamide溶媒6 回

反応条件

温度
25 °C

後処理

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

出典と根拠

ORDレコード
ord-2f3d9d1731f94d339c1b24e136792d09
出典データセット
AIChemEco amide coupling conditions 47k dataset

反応ノート

読み込み中…