tert-Butyl 3-(2-(2-hydroxyethoxy)phenyl)-3-oxopropanoate → Ethyl 3-(2-(2-hydroxyethoxy)phenyl)-3-oxopropanoate

HRID 75553

反応式

HRID 75553 の反応式
[OH:1][CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11](=[O:20])[CH2:12][C:13]([O:15][C:16](C)(C)[CH3:17])=[O:14]>C(O)C>[OH:1][CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11](=[O:20])[CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14]

参加物

3

反応物 1

HCID 86684691tert-Butyl 3-(2-(2-hydroxyethoxy)phenyl)-3-oxopropanoate

生成物 1

HCID 86684692Ethyl 3-(2-(2-hydroxyethoxy)phenyl)-3-oxopropanoate

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

tert-Butyl 3-(2-(2-hydroxyethoxy)phenyl)-3-oxopropanoate (2.0 g, 7.14 mmol) in ethanol (20 mL) was heated in a microwave reactor at 120° C. for 90 min. The mixture was cooled to room temperature and the solvent was concentrated under reduced pressure to give a yellow oil. The crude product was purified by flash chromatography (30-40% EtOAc: petroleum ether) to give the title compound as a yellow solid.

後処理

  1. concentrationthe solvent was concentrated under reduced pressure
  2. customto give a yellow oil
  3. customThe crude product was purified by flash chromatography (30-40% EtOAc: petroleum ether)

出典と根拠

ORDレコード
ord-d7124c86011e4fc69564280a284f777a
出典データセット
uspto-grants-2014_09
特許番号
US08835449B2

関連ノート

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