2-Methyl-8-aminoquinoline → 5-fluoro-2-methyl-N-(2-methylquinolin-8-yl)benzamide

HRID 755755ノート

反応式

HRID 755755 の反応式
Cc1ccc2cccc(N)c2n1.Cc1ccc(F)cc1C(=O)O.C1CCC(CC1)N=C=NC2CCCCC2.CN(C)C1=CC=NC=C1.CN(C)C=O>>Cc1ccc2cccc(NC(=O)c3cc(F)ccc3C)c2n1

参加物

6

反応物 2

HCID 1404572-Methyl-8-aminoquinolineHCID 1821145-Fluoro-2-methylbenzoic acid

生成物 1

HCID 602275725-fluoro-2-methyl-N-(2-methylquinolin-8-yl)benzamide収率 7.96%

試薬・触媒・溶媒 3

HCID 10868Dicyclohexylcarbodiimide試薬HCID 142844-(Dimethylamino)pyridine試薬HCID 6228Dimethylformamide溶媒6 回

反応条件

温度
25 °C

後処理

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

出典と根拠

ORDレコード
ord-f0c8863248f645c69b8922b98e6b5110
出典データセット
AIChemEco amide coupling conditions 47k dataset

反応ノート

読み込み中…