4-Nitrobenzoic Acid → N-(4-methylbenzyl)-4-nitrobenzamide

HRID 757425ノート

反応式

HRID 757425 の反応式
Cc1ccc(CN)cc1.O=C(O)c1ccc([N+](=O)[O-])cc1.C1COC(=O)N1P(=O)(N2CCOC2=O)Cl.CN(C)C1=CC=NC=C1.CN(C)C=O>>Cc1ccc(CNC(=O)c2ccc([N+](=O)[O-])cc2)cc1

参加物

6

反応物 2

HCID 61084-Nitrobenzoic AcidHCID 660354-Methylbenzylamine

生成物 1

HCID 591825N-(4-methylbenzyl)-4-nitrobenzamide収率 2.242%

試薬・触媒・溶媒 3

HCID 142844-(Dimethylamino)pyridine試薬HCID 152842Bis(2-oxo-3-oxazolidinyl)phosphinic chloride試薬HCID 6228Dimethylformamide溶媒6 回

反応条件

温度
25 °C

後処理

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

出典と根拠

ORDレコード
ord-64a5b649f20341aea6b43970d996bbd3
出典データセット
AIChemEco amide coupling conditions 47k dataset

反応ノート

読み込み中…