Ethyl 3-(3-nitrophenyl)isoxazole-5-carboxylate → 3-(3-Amino-phenyl)-isoxazole-5-carboxylic acid ethyl ester

HRID 75767

反応式

HRID 75767 の反応式
C(OC(C1ON=C(C2C=CC(N)=CC=2)C=1)=O)C.[CH2:18]([O:20][C:21]([C:23]1[O:27][N:26]=[C:25]([C:28]2[CH:33]=[CH:32][CH:31]=[C:30]([N+:34]([O-])=O)[CH:29]=2)[CH:24]=1)=[O:22])[CH3:19]>>[CH2:18]([O:20][C:21]([C:23]1[O:27][N:26]=[C:25]([C:28]2[CH:33]=[CH:32][CH:31]=[C:30]([NH2:34])[CH:29]=2)[CH:24]=1)=[O:22])[CH3:19]

参加物

3

反応物 2

HCID 932215Ethyl 3-(3-nitrophenyl)isoxazole-5-carboxylateHCID 53407704Ethyl 3-(4-aminophenyl)isoxazole-5-carboxylate

生成物 1

HCID 673534853-(3-Amino-phenyl)-isoxazole-5-carboxylic acid ethyl ester

実験手順

The title compound was prepared according to the procedure as set forth in Example 1 for the preparation of 3-(4-amino-phenyl)-isoxazol-5-carboxylic acid ethyl ester, except that 3-(3-nitro-phenyl)-isoxazole-5-carboxylic acid ethyl ester was used in place of 3-(4-nitro-phenyl)-isoxazole-5-carboxylic acid ethyl ester. The crude product was purified by flash chromatography with 15% EtOAc in light petroleum. Mass (ES+), 233 (M++1), 255 (M++Na); IR (KBr): 3460, 3369, 1727, 1615, 1431; 1H NMR (CDCl3) 1.43 (t, 3H), 3.83 (s, 2H), 4.45 (q, 2H), 6.78 (m, 1H), 7.13-7.19 (m, 4H).

後処理

  1. customThe crude product was purified by flash chromatography with 15% EtOAc in light petroleum

出典と根拠

ORDレコード
ord-60671cef7d794c1a8b66618287b20077
出典データセット
uspto-grants-2014_09
特許番号
US08835428B2

関連ノート

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