2-Fluorophenyl isocyanate → HCID 67354286、化合物

HRID 75825

反応式

HRID 75825 の反応式
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]=[C:9]=[O:10].[NH2:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[CH:22]=[C:21]([C:23]([NH:25][CH:26]([CH2:31][C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[C:27]([O:29][CH3:30])=[O:28])=[O:24])[O:20][N:19]=2)=[CH:14][CH:13]=1>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9](=[O:10])[NH:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[CH:22]=[C:21]([C:23]([NH:25][CH:26]([CH2:31][C:32]3[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=3)[C:27]([O:29][CH3:30])=[O:28])=[O:24])[O:20][N:19]=2)=[CH:14][CH:13]=1

参加物

3

反応物 2

HCID 855882-Fluorophenyl isocyanateHCID 67355008Methyl 2-(3-(4-aminophenyl)isoxazole-5-carboxamido)-3-phenylpropanoate

生成物 1

HCID 67354286HCID 67354286、化合物収率 88%

実験手順

The title compound was prepared according to the procedure as set forth in example 151, except that 1-fluoro-2-isocyanatobenzene was used in place of 1-fluoro-3-isocyanatobenzene and methyl 2-(3-(4-aminophenyl)isoxazole-5-carboxamido)-3-phenylpropanoate was used in place of methyl 2-(3-(4-aminophenyl)isoxazole-5-carboxamido)-3-methylbutanoate to yield 88% of the title compound. MS (ESI): m/z 503.2 (M+H)+; 1HNMR (DMSO-d6, 300 MHz): δ 9.43 (d, 1H), 9.33 (s, 1H), 8.63 (s, 1H), 8.16 (dt, 1H), 7.84 (d, 2H), 7.61 (d, 2H), 7.56 (s, 1H), 7.27 (d, 4H), 7.23 (m, 2H), 7.15 (t, 1H), 7.00 (m, 1H), 4.74 (m, 1H), 3.65 (s, 3H), 3.23 (m, 2H).

後処理

  1. customThe title compound was prepared

出典と根拠

ORDレコード
ord-719b4d9698e34c2993654d4bed0cc8b8
出典データセット
uspto-grants-2014_09
特許番号
US08835428B2

関連ノート

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