反応式
[F:1][C:2]1[CH:12]=[CH:11][C:5]([CH:6]=[CH:7][C:8]([OH:10])=O)=[CH:4][CH:3]=1.[N:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[N:19]1[CH2:24][CH2:23][N:22]([C:25]2[CH:26]=[C:27]([C@@H:31]([NH2:33])[CH3:32])[CH:28]=[CH:29][CH:30]=2)[CH2:21][CH2:20]1.C(Cl)CCl.C(N(CC)CC)C>CN(C1C=CN=CC=1)C.ClCCl>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH:6]=[CH:7][C:8]([NH:33][C@H:31]([C:27]2[CH:28]=[CH:29][CH:30]=[C:25]([N:22]3[CH2:21][CH2:20][N:19]([C:14]4[CH:15]=[CH:16][CH:17]=[CH:18][N:13]=4)[CH2:24][CH2:23]3)[CH:26]=2)[CH3:32])=[O:10])=[CH:11][CH:12]=1参加物
7
反応物 4
生成物 1
試薬・触媒・溶媒 2
実験手順
A solution of 4-fluorocinnamic acid (17 mg, 0.1 mmol), (S)-1-[3-(4-pyridin-2-yl-piperazin-1-yl)phenyl]ethylamine (24 mg, 0.11 mmol), EDC (28 mg, 0.15 mmol), DMAP (12 mg, 0.1 mmol) and triethylamine (40 mg, 0.4 mmol) in dichloromethane (2 ml) was stirred at room temperature for 14 h. The reaction mixture was purified by flash chromatography over silica gel with ethyl acetate/hexanes (1:1) to give the title compound as a solid (26 mg, 60% yield).
後処理
- customThe reaction mixture was purified by flash chromatography over silica gel with ethyl acetate/hexanes (1:1)
出典と根拠
- ORDレコード
- ord-e9942dd2878d4dca917c28cc1fed1a55
- 出典データセット
- uspto-grants-2006_08
- 特許番号
- US07087609B2
関連ノート
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