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HRID 76009作成日：2026年10月23日
Tetrahydrofuran → N-[4-chloro-2-(triazolo[4,5-b]pyridin-1-yl)phenyl]-4-[(E)-N-hydroxy-C-methylcarbonimidoyl]benzenesulfonamide
https://huagongshe.com/ja/reaction/76009
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | Hydroxyamine hydrochloride | HCID 443297 | — |
| 反応物 | 4-acetyl-N-(4-chloro-2-[1,2,3]triazolo[4,5-b]pyridin-1-yl-phenyl)benzenesulfonamide | HCID 57378404 | — |
| 触媒 | Titanium tetraethoxide | HCID 76524 | — |
| 溶媒 | Acetonitrile--water (1/1) | HCID 18373917 | — |
| 生成物 | N-[4-chloro-2-(triazolo[4,5-b]pyridin-1-yl)phenyl]-4-[(E)-N-hydroxy-C-methylcarbonimidoyl]benzenesulfonamide | HCID 59428153 | — |
反応手順
A 4 mL vial was charged with 4-acetyl-N-(4-chloro-2-[1,2,3]triazolo[4,5-b]pyridin-1-yl-phenyl)-benzenesulfonamide (synthesized according to general procedures F and G, 100 mg, 0.23 mmol), hydroxylamine hydrochloride (49 mg, 0.70 mmol), and 2 mL THF. The resultant slurry was mixed well, then titanium ethoxide (98 μL, 47 mmol) was added and the mixture heated to 60° C. overnight. The reaction mixture was subsequently diluted with ˜2 mL of acetonitrile/H2O and purified by reversed phase HPLC to afford N-(4-chloro-2-[1,2,3]triazolo[4,5-b]pyridin-1-yl-phenyl)-4-{1-[(E)-hydroxyimino]-ethyl}benzenesulfonamide: MS (ES) M+H expected 443.0, found 443.0.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08835468B2 |
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| 出典データセット | uspto-grants-2014_09 |
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| ORD ID | ord-21578a6e5afc47588c98aebf27174ab7 |
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| 出典メモ | uspto-grants-2014_09 |
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