Potassium Carbonate → 2-Ethynyl-5-isopropoxypyridine

HRID 76124

反応式

HRID 76124 の反応式
[CH:1]([O:4][C:5]1[CH:6]=[CH:7][C:8]([CH:11]=O)=[N:9][CH:10]=1)([CH3:3])[CH3:2].[C:13]([O-])([O-])=O.[K+].[K+].[N+](=C(P(=O)(OC)OC)C(=O)C)=[N-]>CO.CCOC(C)=O>[C:11]([C:8]1[CH:7]=[CH:6][C:5]([O:4][CH:1]([CH3:3])[CH3:2])=[CH:10][N:9]=1)#[CH:13]

参加物

6

反応物 3

HCID 11430Potassium CarbonateHCID 797940465-IsopropoxypicolinaldehydeHCID 136023029(1E)-1-diazo-1-dimethoxyphosphorylpropan-2-one

生成物 1

HCID 747887042-Ethynyl-5-isopropoxypyridine

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To 1.00 g (6.05 mmol) 5-isopropoxypicolinaldehyde in 20 mL methanol are added 1.67 g (12.1 mmol) K2CO3 followed by 1.4 g (7.26 mmol) dimethyl 1-diazo-2-oxopropylphosphonate. After stirring at r.t. over the weekend the reaction mixture is diluted with EtOAc and washed consecutively with NaHCO3 solution and water. The organic layer is dried with Na2SO4 and the solvent is removed in vacuo.

後処理

  1. washwashed consecutively with NaHCO3 solution and water
  2. dry with materialThe organic layer is dried with Na2SO4
  3. customthe solvent is removed in vacuo

出典と根拠

ORDレコード
ord-a170e6da9b254ca38b9dff72e944b64c
出典データセット
uspto-grants-2014_09
特許番号
US08835472B2

関連ノート

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