関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Monobenzone | HCID 7638 | — |
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | 5-Bromopyrimidine | HCID 78344 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 5-(p-Hydroxyphenoxy)pyrimidine | HCID 12940620 | — |
反応手順
To 1.00 g (4.99 mmol) 4-(benzyloxy)phenol and 794 mg (4.99 mmol) 5-bromo-pyrimidine in 5 mL DMF are added 3.25 g (9.99 mmol) Cs2CO3 and the reaction mixture is stirred at 120° C. for 6 h in a microwave oven. Then the reaction mixture is diluted with water and extracted with EtOAc. The organic layer is dried with Na2SO4 and the solvent is removed in vacuo. The residue is purified by HPLC (MeOH/H2O/NH3).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08835472B2 |
|---|
| 出典データセット | uspto-grants-2014_09 |
|---|
| ORD ID | ord-e7978093a2dc4120954dbcd795fa8f7e |
|---|
| 出典メモ | uspto-grants-2014_09 |
|---|
