2-(4-Bromophenyl)propanenitrile → 2-(4-Bromophenyl)propan-1-amine

HRID 76145ノート

反応式

HRID 76145 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH3:11])[C:9]#[N:10])=[CH:4][CH:3]=1>[Ni].N>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([CH3:11])[CH2:9][NH2:10])=[CH:6][CH:7]=1

参加物

4

反応物 1

HCID 107509272-(4-Bromophenyl)propanenitrile

生成物 1

HCID 107986602-(4-Bromophenyl)propan-1-amine

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 222Ammonia溶媒

実験手順

A mixture of 3.00 g (14.3 mmol) 2-(4-bromo-phenyl)-propionitrile and 40 mL ammonia solution (7N in methanol) is charged with 0.30 g Raney nickel. The mixture is stirred under an atmosphere of hydrogen (50 psi) at r.t. for 34 h. The mixture is filtered and the solvent is removed in vacuo. The crude product is used without further purification.

後処理

  1. filtrationThe mixture is filtered
  2. customthe solvent is removed in vacuo
  3. customThe crude product is used without further purification

出典と根拠

ORDレコード
ord-5ebc63f5e247468e89ccb9bbfd6ddfc8
出典データセット
uspto-grants-2014_09
特許番号
US08835472B2

反応ノート

読み込み中…