p-Bromoacetophenone → 2-(4-Bromophenyl)propan-2-ol

HRID 76160

反応式

HRID 76160 の反応式
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([Br:10])=[CH:6][CH:5]=1)=[O:3].[CH3:11][Mg+].[Br-]>C(OCC)C>[Br:10][C:7]1[CH:8]=[CH:9][C:4]([C:2]([OH:3])([CH3:11])[CH3:1])=[CH:5][CH:6]=1

参加物

4

反応物 2

HCID 7466p-BromoacetophenoneHCID 178418689HCID 178418689、化合物

生成物 1

HCID 126819202-(4-Bromophenyl)propan-2-ol

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

反応条件

温度
0 °C

実験手順

20.0 g (100 mmol) 4-bromoacetophenone are added to 300 mL diethylether and cooled down to 0° C. 35.2 mL MeMgBr (3M in diethylether) are added by a dropping funnel. Cooling is removed and the mixture is stirred at r.t. over night. The reaction quenched by careful addition of 150 mL sat. aq. NH4Cl solution and 150 mL water. The resulting mixture is stirred for 20 min. The layers are separated and the org. layer is washed with water (2×), dried with MgSO4 and the solvent is removed in vacuo.

後処理

  1. temperatureCooling
  2. customis removed
  3. customThe reaction quenched by careful addition of 150 mL sat. aq. NH4Cl solution and 150 mL water
  4. stirringThe resulting mixture is stirred for 20 min
  5. customThe layers are separated
  6. washlayer is washed with water (2×)
  7. dry with materialdried with MgSO4
  8. customthe solvent is removed in vacuo

出典と根拠

ORDレコード
ord-bc092db86e90497488c901f7343b86e1
出典データセット
uspto-grants-2014_09
特許番号
US08835472B2

関連ノート

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