N-(1-(4-Iodophenyl)propan-2-YL)acetamide → 4-Iodo-alpha-methylbenzeneethanamine

HRID 76163ノート

反応式

HRID 76163 の反応式
[I:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH:9]([NH:11]C(=O)C)[CH3:10])=[CH:4][CH:3]=1>Cl>[I:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH:9]([NH2:11])[CH3:10])=[CH:6][CH:7]=1

参加物

3

反応物 1

HCID 66611344N-(1-(4-Iodophenyl)propan-2-YL)acetamide

生成物 1

HCID 1238704-Iodo-alpha-methylbenzeneethanamine

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

9.00 g (29.69 mmol) N-[2-(4-iodo-phenyl)-1-methyl-ethyl]-acetamide (I52.1) are added to 150 mL HCl (4N) and the reaction mixture is stirred at reflux over night. Then the mixture is diluted with soda lye and extracted with EtOAc. The organic layer is dried with Na2SO4 and the solvent is removed in vacuo.

後処理

  1. temperatureat reflux over night
  2. additionThen the mixture is diluted with soda lye
  3. extractionextracted with EtOAc
  4. dry with materialThe organic layer is dried with Na2SO4
  5. customthe solvent is removed in vacuo

出典と根拠

ORDレコード
ord-6972a19953ff4a0ca677f361275db46a
出典データセット
uspto-grants-2014_09
特許番号
US08835472B2

反応ノート

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