Hydrochloric Acid → 1-(4-((4-Ethoxyphenyl)ethynyl)phenyl)propan-2-amine hydrochloride

HRID 76172

反応式

HRID 76172 の反応式
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]#[C:11][C:12]2[CH:17]=[CH:16][C:15]([CH2:18][CH:19]([NH:21]C(=O)OC(C)(C)C)[CH3:20])=[CH:14][CH:13]=2)=[CH:6][CH:5]=1)[CH3:2].[ClH:29]>CO>[ClH:29].[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]#[C:11][C:12]2[CH:13]=[CH:14][C:15]([CH2:18][CH:19]([NH2:21])[CH3:20])=[CH:16][CH:17]=2)=[CH:6][CH:5]=1)[CH3:2]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 66611490Tert-butyl 1-(4-((4-ethoxyphenyl)ethynyl)phenyl)propan-2-yl-carbamate

生成物 1

HCID 666106811-(4-((4-Ethoxyphenyl)ethynyl)phenyl)propan-2-amine hydrochloride

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
70 °C

実験手順

To 3.30 g (8.70 mmol) tert-butyl 1-(4-((4-ethoxyphenyl)ethynyl)phenyl)propan-2-yl-carbamate (I60) in 40 mL MeOH are added 20 mL (25 mmol) HCl (1.25M in MeOH). The mixture is stirred at 70° C. for 7 h. The solvent is removed in vacuo and the crude product is triturated with DIPE and dried in normal atmosphere.

後処理

  1. customThe solvent is removed in vacuo
  2. customthe crude product is triturated with DIPE
  3. customdried in normal atmosphere

出典と根拠

ORDレコード
ord-9977905a0b844ee4aae5f5837004ce90
出典データセット
uspto-grants-2014_09
特許番号
US08835472B2

関連ノート

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