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Water → N-(1-(4-((4-Chlorophenyl)ethynyl)phenyl)propan-2-yl)acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Benzene, 1-chloro-4-ethynyl- | HCID 70118 | — |
| 反応物 | N-(1-(4-Iodophenyl)propan-2-YL)acetamide | HCID 66611344 | — |
| 触媒 | HCID 178418476 | HCID 178418476 | — |
| 溶媒 | Sec-Butylamine | HCID 24874 | — |
| 生成物 | N-(1-(4-((4-Chlorophenyl)ethynyl)phenyl)propan-2-yl)acetamide | HCID 56924958 | — |
反応手順
To 45.5 mg (0.15 mmol) N-(1-(4-iodophenyl)propan-2-yl)acetamide (I52.1) and 27.3 mg (0.20 mmol) 1-chloro-4-ethynylbenzene in 750 μl sec-butylamine are added 14.3 (0.02 mmol) bis(triphenyphosphine)dichloropalladium (in 400 μl sec-butylamine) followed by 1.0 mL water. The reaction mixture is stirred at r.t. overnight. The solvent is removed in vacuo and the residue is purified by HPLC (ACN/H2O/TFA).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08835472B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-7ab3636260214442aeb49d5e398ff055 |
| 出典メモ | uspto-grants-2014_09 |