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Triethylamine → HCID 178418938、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 2,4,6-Trichloropyrimidine | HCID 77378 | — |
| 反応物 | 3-cyclopropyl-1H-pyrazol-5-amine | HCID 2758014 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | HCID 178418938 | HCID 178418938 | 80% |
反応手順
To a solution of-2,4,6-trichloropyrimidine (600 mg, 3.27 mmol) and 3-amino-5-cyclopropylpyrazole (403 mg, 3.27 mmol) in EtOH (10 mL) was added triethylamine (456 μL, 3.27 mmol) and the reaction mixture was stirred for 15 hours at room temperature. The solvent was evaporated and the residue was purified by flash chromatography (SiO2, Hexane/AcOEt gradient) to afford (5-cyclopropyl-2H-pyrazol-3-yl-)-(2,6-dichloropyrimidin-4-yl)-amine (705 mg, 80%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07087603B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-35c861d6b82946f599930c0c25b7c1b1 |
| 出典メモ | uspto-grants-2006_08 |