Hydrochloric Acid → N-[3-(acetylmethylamino)-2-hydroxypropyl]-N-methylacetamide
反応式
[C:1]([CH2:4][NH:5][CH2:6][CH:7]([O:14][Si](C(C)(C)C)(C)C)[CH2:8][N:9]([CH3:13])[C:10](=[O:12])[CH3:11])(=[O:3])[CH3:2].Cl>CO>[C:1]([CH2:4][NH:5][CH2:6][CH:7]([OH:14])[CH2:8][N:9]([CH3:13])[C:10](=[O:12])[CH3:11])(=[O:3])[CH3:2]参加物
4
実験手順
To a solution of N-[3-(acetylmethylamino)-2-(tert-butyldimethyl silanyloxy)propyl]-N-methylacetamide (1.12 g, 3.54 mmol) in methanol (23 mL), hydrogen chloride 4M dioxane solution (0.357 mL, 1.426 mmol) was added dropwise at 0° C. and the reaction was stirred at r.t. overnight. Solvent was evaporated and the residue triturated with petroleum ether and decanted. The oil obtained after trituration was dried under vacuum affording N-[3-(acetylmethylamino)-2-hydroxypropyl]-N-methylacetamide (681 mg, 95% yield).
後処理
- customSolvent was evaporated
- customthe residue triturated with petroleum ether
- customdecanted
- customThe oil obtained after trituration
- customwas dried under vacuum
出典と根拠
- ORDレコード
- ord-1eca467bf16343c4bf56a6b7ef36026a
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08835494B2
反応ノート
読み込み中…