1-(3',4'-Dichloro-2-fluorobiphenyl-4-yl)cyclopropane carboxylic acid 2-acetylmethylamino-1-(acetylmethylaminomethyl)ethyl ester → Acetic acid 1-[(acetylmethylamino)methyl]-2-{[1-(3',4'-dichloro-2-fluorobiphenyl-4-yl)cyclopropanecarbonyl]-methylamino}ethyl ester

HRID 76242ノート

反応式

HRID 76242 の反応式
C(CNCC(O[C:15]([C:17]1([C:20]2[CH:25]=[CH:24][C:23]([C:26]3[CH:31]=[CH:30][C:29]([Cl:32])=[C:28]([Cl:33])[CH:27]=3)=[C:22]([F:34])[CH:21]=2)[CH2:19][CH2:18]1)=[O:16])CNCC(=O)C)(=O)C.C([CH2:38][NH:39][CH2:40][CH:41]([O:65][C:66](=[O:68])[CH3:67])[CH2:42][NH:43][CH2:44][C:45]([C:47]1(C2C=CC(C3C=CC(Cl)=C(Cl)C=3)=C(F)C=2)CC1)=[O:46])(=O)C>CN(C1C=CN=CC=1)C>[C:45]([CH2:44][NH:43][CH2:42][CH:41]([O:65][C:66](=[O:68])[CH3:67])[CH2:40][N:39]([C:15]([C:17]1([C:20]2[CH:25]=[CH:24][C:23]([C:26]3[CH:31]=[CH:30][C:29]([Cl:32])=[C:28]([Cl:33])[CH:27]=3)=[C:22]([F:34])[CH:21]=2)[CH2:19][CH2:18]1)=[O:16])[CH3:38])(=[O:46])[CH3:47]

参加物

4

反応物 2

HCID 866988931-(3',4'-Dichloro-2-fluorobiphenyl-4-yl)cyclopropane carboxylic acid 2-acetylmethylamino-1-(acetylmethylaminomethyl)ethyl ester2 回HCID 86698894Acetic acid 1-[(acetylmethylamino)methyl]-2-{[1-(3',4'-dichloro-2-fluorobiphenyl-4-yl)cyclopropanecarbonyl]methylamino}ethyl ester

生成物 1

HCID 86698892Acetic acid 1-[(acetylmethylamino)methyl]-2-{[1-(3',4'-dichloro-2-fluorobiphenyl-4-yl)cyclopropanecarbonyl]-methylamino}ethyl ester

試薬・触媒・溶媒 1

HCID 142844-(Dimethylamino)pyridine触媒

実験手順

Note that although the procedure is similar to that utilized to synthesize C4 (second method, see Example 5), with the exception that also DMAP was added in the coupling step of Example 5 but not of Example 6, the isolated product is different, being acetic acid 1-[(acetylmethylamino)methyl]-2-{[1-(3′,4′-dichloro-2-fluorobiphenyl-4-yl)cyclopropanecarbonyl]methylamino}ethyl ester in Example 6 and 1-(3′,4′-dichloro-2-fluorobiphenyl-4-yl)cyclopropane carboxylic acid 2-acetylmethylamino-1-(acetylmethylaminomethyl)ethyl ester in Example 5.

出典と根拠

ORDレコード
ord-2ade16eee5484b7081ed8e646a8ab0a8
出典データセット
uspto-grants-2014_09
特許番号
US08835494B2

反応ノート

読み込み中…