関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-Methoxyethanol | HCID 8019 | — |
| 反応物 | Formamidine acetate | HCID 160693 | — |
| 反応物 | 4-Fluoroanthranilic acid | HCID 2724967 | — |
| 反応物 | 7-Fluoroquinazolin-4(3H)-one | HCID 135398496 | — |
| 溶媒 | Ammonia | HCID 222 | — |
| 生成物 | 2-[7-(3-Fluoro-benzyloxy)-4-oxo-4H-quinazolin-3-yl]-acetamide | HCID 9862180 | 81% |
反応手順
7-Fluoro-3H-quinazolin-4-one: A mixture of 2-amino-4-fluorobenzoic acid (14.6 g, 94 mmol) and formamidine acetate (19.6 g, 18.8 mmol) in 2-methoxyethanol (110 mL) was heated at 130° C. for 18 h. After cooling, the mixture was half evaporated and an off-white solid formed. The mixture was diluted with ammonia (25%, 10 mL in 90 mL water) and the solid filtered off and washed with water. The solid was then washed with hexane and dried under high vacuum to afford the title compound (12.5 g, 81%) as an off-white solid. MS: m/e=165.2 (M+H+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07087612B2 |
|---|
| 出典データセット | uspto-grants-2006_08 |
|---|
| ORD ID | ord-7db9ee3861144166bfa97d305c987b83 |
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| 出典メモ | uspto-grants-2006_08 |
|---|
