Trimethylamine oxide → 2,2-Dimethyl-6-oxohexanenitrile
反応式
C[N+]([O-:5])(C)C.Br[CH2:7][CH2:8][CH2:9][CH2:10][C:11]([CH3:15])([CH3:14])[C:12]#[N:13]>CS(C)=O>[CH3:14][C:11]([CH3:15])([CH2:10][CH2:9][CH2:8][CH:7]=[O:5])[C:12]#[N:13]参加物
4
実験手順
To a suspension of trimethylamine oxide (1.5 g, 19.6 mmol, Aldrich) in DMSO (10 mL) was added 6-bromo-2,2-dimethylhexanenitrile (0.84 mL, 4.9 mmol, Aldrich). After stirring at room temperature overnight, the reaction mixture was quenched with water (10 mL) and extracted with hexanes (4×10 mL). The combined organic extracts were washed with brine (20 mL), dried (NaSO4), filtered and concentrated to afford 0.65 g (80% pure) of the title compound. MS (ESI+) m/z 157 (M+NH4)+.
後処理
- customthe reaction mixture was quenched with water (10 mL)
- extractionextracted with hexanes (4×10 mL)
- washThe combined organic extracts were washed with brine (20 mL)
- dry with materialdried (NaSO4)
- filtrationfiltered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-2e8db837b5104b6794378b445eb20a15
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08835475B2
反応ノート
読み込み中…