化工社化工社 化学情報印刷レポート · 研究参考用
Triethylamine → Ethyl N-(4-chloro-2-pyrimidinyl)-N-methylglycinate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 2,4-Dichloropyrimidine | HCID 77531 | — |
| 反応物 | Glycine, N-methyl-, ethyl ester | HCID 95849 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | Ethyl N-(4-chloro-2-pyrimidinyl)-N-methylglycinate | HCID 12056459 | — |
反応手順
30.0 g (0.20 mol) of 2,4-dichloropyrimidine, 30.9 g (0.20 mol) of ethyl N-methylglycinate and 61.0 g (0.60 mol) of triethylamine in 200 ml of dioxane are stirred at 50° C. for 10 min. The mixture is filtered off with suction and the mother liquor is concentrated to half the original volume. A solid crystallizes out, which is filtered off with suction. The mother liquor is concentrated, the residue is stirred with petroleum ether and the product is filtered off.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07087616B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-8cdd1682398d44799c23b12882d311f3 |
| 出典メモ | uspto-grants-2006_08 |