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Butanoic acid, 2-bromo-, ethyl ester → 8-bromo-2-ethyl-2H-benzo[b][1,4]oxazin-3(4H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Butanoic acid, 2-bromo-, ethyl ester | HCID 79039 | — |
| 反応物 | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| 反応物 | 2-Amino-6-bromophenol | HCID 15531506 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | 8-bromo-2-ethyl-2H-benzo[b][1,4]oxazin-3(4H)-one | HCID 66715230 | 71% |
反応手順
Procedure & NMR Data: 1.5 g (7.9 mmol) of 2-bromo-6-aminophenol, 1.08 ml (0.9 eq, 7.11 mmol) of 1.8-diazabicyclo[5.4.0]undec-7-ene and 3.5 mL of DL-Ethyl 2-bromobutyrate (3 eq, 23.7 mmol)) in 30 mL of 1-Methyl-2-pyrrolidinone were mixed. 1.447 g of P1 were obtained, yield 71%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08835628B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-efd9c31ad02147a0b0605978b604591c |
| 出典メモ | uspto-grants-2014_09 |