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Water → N-(2,2-difluoroethyl)-2-nitroaniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 1-Chloro-2-nitrobenzene | HCID 6945 | — |
| 反応物 | 2,2-Difluoroethanamine | HCID 136274 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | N-(2,2-difluoroethyl)-2-nitroaniline | HCID 58110950 | 95% |
反応手順
2 ml (19 mM) of 2-Chloronitrobenzene and 2.7 ml (36 mM) of 2,2-difluoroethyl amine in 2 ml of acetonitrile were refluxed under stirring for 24 h. Water was added and the aqueous layer was extracted with ethyl acetate. The organic layer was washed with water and dried over anhydrous sodium sulfate. The solvent was removed under vacuum to give 3.65 g of N-(2,2-difluoroethyl)-2-nitroaniline as an orange solid. Yield: 95%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08835634B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-7d277d5a0c004e918e97e3f25455b131 |
| 出典メモ | uspto-grants-2014_09 |