2-[2-(9H-carbazol-1-ylamino)phenyl]propan-2-ol → 7,7-dimethyl-12,13-dihydro-7H-indolo[3,2-c]acridine

HRID 76380ノート

反応式

HRID 76380 の反応式
[C:1]1([NH:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[C:21](O)([CH3:23])[CH3:22])[C:13]2[NH:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1>O>[CH3:22][C:21]1([CH3:23])[C:2]2[CH:3]=[CH:4][C:5]3[C:6]4[CH:7]=[CH:8][CH:9]=[CH:10][C:11]=4[NH:12][C:13]=3[C:1]=2[NH:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]1=2

参加物

3

反応物 1

HCID 674045002-[2-(9H-carbazol-1-ylamino)phenyl]propan-2-ol

生成物 1

HCID 674033727,7-dimethyl-12,13-dihydro-7H-indolo[3,2-c]acridine

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
0 °C

実験手順

63 g (200 mmol) of 2-[2-(9H-carbazol-1-ylamino)phenyl]propan-2-ol are initially introduced in 268 g (2734 mmol) of polyphosphoric acid under protective gas and cooled to 0° C. The mixture is subsequently stirred at 100° C. for 3 h and then cooled to room temperature. Water is added to the mixture with ice cooling, the mixture is extracted with ethyl acetate, and the solvent is removed in vacuo. The content of product according to 1H-NMR is about 96% with an overall yield of 53 g (90%).

後処理

  1. temperaturecooled to room temperature
  2. extractionthe mixture is extracted with ethyl acetate
  3. customthe solvent is removed in vacuo

出典と根拠

ORDレコード
ord-6cee9cc7d498451f963df8108bf9e05c
出典データセット
uspto-grants-2014_09
特許番号
US08835626B2

反応ノート

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