化工社化工社 化学情報印刷レポート · 研究参考用
3-Aminobiphenyl → N2,N4-bis[(3-phenyl)phenyl]-5-fluoro-2,4-pyrimidinediamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Aminobiphenyl | HCID 16717 | — |
| 反応物 | 2,4-Dichloro-5-fluoropyrimidine | HCID 250705 | — |
| 生成物 | N2,N4-bis[(3-phenyl)phenyl]-5-fluoro-2,4-pyrimidinediamine | HCID 66759549 | — |
反応手順
In like manner to the preparation of N2,N4-bis(3-hydroxyphenyl)-5-fluoro-2,4-pyrimidinediamine, 2,4-dichloro-5-fluoropyrimidine and 3-phenylaniline were reacted to yield N2,N4-bis[(3-phenyl)phenyl]-5-fluoro-2,4-pyrimidinediamine. 1H NMR (CD3OD): δ 8.02 (d, 1H, J=5.1 Hz), 7.82 (t, 1H, J=1.5 Hz), 7.67 (t, 1H, J=1.8 Hz), 7.58 (dd, 1H, J=1.2 and 7.2 Hz), 7.42-7.24 (m, 15H); LCMS: ret. time: 32.06 min.; purity: 94%; MS (m/e): 433 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08835430B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-c1b140d3bce04315a3393dc9f9a8d455 |
| 出典メモ | uspto-grants-2014_09 |