4-Amino-2,6-dichlorophenol → N2,N4-bis-(3,5-dichloro-4-hydroxyphenyl)-5-fluoro-2,4-pyrimidinediamine

HRID 76493

反応式

HRID 76493 の反応式
Cl[C:2]1[N:7]=[C:6](Cl)[C:5]([F:9])=[CH:4][N:3]=1.[Cl:10][C:11]1[CH:12]=[C:13]([CH:15]=[C:16]([Cl:19])[C:17]=1[OH:18])[NH2:14]>>[Cl:10][C:11]1[CH:12]=[C:13]([NH:14][C:2]2[N:7]=[C:6]([NH:14][C:13]3[CH:12]=[C:11]([Cl:10])[C:17]([OH:18])=[C:16]([Cl:19])[CH:15]=3)[C:5]([F:9])=[CH:4][N:3]=2)[CH:15]=[C:16]([Cl:19])[C:17]=1[OH:18]

参加物

3

反応物 2

HCID 800374-Amino-2,6-dichlorophenolHCID 2507052,4-Dichloro-5-fluoropyrimidine

生成物 1

HCID 22060750N2,N4-bis-(3,5-dichloro-4-hydroxyphenyl)-5-fluoro-2,4-pyrimidinediamine

実験手順

In like manner to the preparation of N2,N4-bis(3-hydroxyphenyl)-5-fluoro-2,4-pyrimidinediamine, the reaction of 2,4-dichloro-5-fluoropyrimidine with 3,5-dichloro-4-hydroxyaniline gave N2,N4-bis-(3,5-dichloro-4-hydroxyphenyl)-5-fluoro-2,4-pyrimidinediamine. LCMS: ret. time: 21.26 min.; purity: 88%; MS (m/e): 450 (M+); 1H NMR (DMSO-d6): δ 9.96 (1H, s), 9.59 (1H, s), 9.47 (1H, s), 9.37 (1H, s), 8.22 (1H, d, J=3.6 Hz), 7.79 (2H, s), 7.74 (2H, s).

後処理

  1. customIn like manner to the preparation of N2,N4-bis(3-hydroxyphenyl)-5-fluoro-2,4-pyrimidinediamine

出典と根拠

ORDレコード
ord-87f0e7ba8d30408d86ae2e48a0401594
出典データセット
uspto-grants-2014_09
特許番号
US08835430B2

関連ノート

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