Furfurylamine → N2,N4-bis(furfuryl)-5-fluoro-2,4-pyrimidinediamine

HRID 76502

反応式

HRID 76502 の反応式
[OH:1][C:2]1C=[C:4]([NH:8][C:9]2[N:14]=[C:13]([NH:15][C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([OH:22])C=3)[C:12]([F:23])=[CH:11][N:10]=2)[CH:5]=[CH:6][CH:7]=1.ClC1N=C(Cl)C(F)=CN=1.C(N)C1OC=CC=1>>[CH2:4]([NH:8][C:9]1[N:14]=[C:13]([NH:15][CH2:16][C:21]2[O:22][CH:18]=[CH:19][CH:20]=2)[C:12]([F:23])=[CH:11][N:10]=1)[C:5]1[O:1][CH:2]=[CH:7][CH:6]=1

参加物

4

反応物 3

HCID 3438FurfurylamineHCID 2507052,4-Dichloro-5-fluoropyrimidineHCID 9904854R-112

生成物 1

HCID 22060499N2,N4-bis(furfuryl)-5-fluoro-2,4-pyrimidinediamine

実験手順

In a manner similar to the preparation of N2,N4-bis(3-hydroxyphenyl)-5-fluoro-2,4-pyrimidinediamine, 2,4-dichloro-5-fluoropyrimidine and furfurylamine were reacted to yield N2,N4-bis(furfuryl)-5-fluoro-2,4-pyrimidinediamine. 1H NMR (CDCl3): δ 7.72 (bs, 1H), 7.38 (dd, 2H, J=1.8 and 7.5 Hz), 6.34-6.30 (m, 2H), 6.22 (dd, 2H, J=2.4 and 9.9 Hz), 5.163 (bs, 2H), 4.63 (d, 2H, J=6.0), 4.54 (d, 2H, J=6.0); 19F NMR (CDCl3): −48621; LCMS: ret. time: 97.27 min.; purity: 97%; MS (m/e): 289 (MH+).

後処理

  1. customwere reacted

出典と根拠

ORDレコード
ord-da04fee5eca644c3a5ef98cd3eb09bcd
出典データセット
uspto-grants-2014_09
特許番号
US08835430B2

関連ノート

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