Methanol → Methyl p-aminosalicylate

HRID 76646

反応式

HRID 76646 の反応式
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([OH:11])[CH:3]=1.[CH3:12]O>>[OH:11][C:4]1[CH:3]=[C:2]([CH:10]=[CH:9][C:5]=1[C:6]([O:8][CH3:12])=[O:7])[NH2:1]

参加物

3

反応物 2

HCID 887MethanolHCID 46494-Aminosalicylic Acid

生成物 1

HCID 77787Methyl p-aminosalicylate

実験手順

A solution of 4-amino-2-hydroxybenzoic acid (1 g, 6.5 mmol) in MeOH (15 mL) and concentrated sulfonic acid (1 mL) was refluxed overnight. The reaction mixture was quenched with NaHCO3 aqueous solution (60 mL) and EtOAc (60 mL). The organic layer was separated, dried, evaporated to give 3-hydroxy-4-methoxycarbonylaniline.

後処理

  1. customThe reaction mixture was quenched with NaHCO3 aqueous solution (60 mL) and EtOAc (60 mL)
  2. customThe organic layer was separated
  3. customdried
  4. customevaporated

出典と根拠

ORDレコード
ord-e159ba31816b4b928b6553cecf01fe6b
出典データセット
uspto-grants-2014_09
特許番号
US08835430B2

関連ノート

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