Azepane → N-{(S)-2-Azepan-1-yl-1-[5-(5-chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-2-oxo-ethyl}-2-chloro-3-(3-oxo-morpholin-4-yl)benzenesulfonamide

関与物質

役割	名称	HCID	仕込み量
反応物	Azepane	HCID 8119	—
反応物	(S)-2-[2-Chloro-3-(3-oxo-morpholin-4-yl)-benzenesulfonylamino]-3-[5-(5-chloro-thiophen-2-yl)-isoxazol-3-yl]-propionic acid	HCID 66911183	—
生成物	N-{(S)-2-Azepan-1-yl-1-[5-(5-chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-2-oxo-ethyl}-2-chloro-3-(3-oxo-morpholin-4-yl)benzenesulfonamide	HCID 66911166	—

Intermediate 12 (300 mg, 0.55 mmol) and azepane (54 mg, 0.55 mmol) were coupled using the procedure described in example 1; 1.9.