3,5-Dimethoxyphenol → 4-(4,6-Dimethoxy-1-benzofuran-2-yl)benzonitrile

HRID 76826

反応式

HRID 76826 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5](O)[CH:6]=[C:7]([O:9][CH3:10])[CH:8]=1.Br[CH2:13][C:14]([C:16]1[CH:23]=[CH:22][C:19]([C:20]#[N:21])=[CH:18][CH:17]=1)=[O:15]>>[CH3:1][O:2][C:3]1[C:4]2[CH:13]=[C:14]([C:16]3[CH:23]=[CH:22][C:19]([C:20]#[N:21])=[CH:18][CH:17]=3)[O:15][C:5]=2[CH:6]=[C:7]([O:9][CH3:10])[CH:8]=1

参加物

3

反応物 2

HCID 103833,5-DimethoxyphenolHCID 986544-(Bromoacetyl)benzonitrile

生成物 1

HCID 545908734-(4,6-Dimethoxy-1-benzofuran-2-yl)benzonitrile収率 24%

実験手順

This compound was prepared using Method A from 3,5-dimethoxyphenol and 4-(2-bromoacetyl)benzonitrile: Yield 24% following procedure A.2; m.p. 220-221° C.; IR 3042, 2955, 2223, 1600, 1507, 1217, 1145, 1104 cm−1; 1H-NMR (500 MHz, δ ppm, CDCl3) 7.84 (d, J=8.2 Hz, 2H), 7.67 (d, J=8.3 Hz, 2H), 7.18 (s, 1H), 6.68 (s, 1H), 6.34 (s, 1H), 3.92 (s, 3H), 3.87 (s, 3H); 13C-NMR (126 MHz, δ ppm, CDCl3) 160.5, 157.4, 154.2, 151.6, 134.9, 132.8, 124.5, 119.1, 113.4, 110.8, 102.4, 94.9, 88.4, 56.1, 55.9.

後処理

  1. customThis compound was prepared

出典と根拠

ORDレコード
ord-8d2ae05ebc3e4110bf3160f243ab31b6
出典データセット
uspto-grants-2014_09
特許番号
US08835659B2

関連ノート

読み込み中…