3,5-Dimethoxyphenol → 2-(2,6-Dimethoxypyridin-3-yl)benzofuran-4,6-diol

HRID 76831

反応式

HRID 76831 の反応式
C[O:2][C:3]1[CH:4]=[C:5](O)[CH:6]=[C:7]([O:9]C)[CH:8]=1.Br[CH2:13][C:14]([C:16]1[C:17]([O:24][CH3:25])=[N:18][C:19]([O:22][CH3:23])=[CH:20][CH:21]=1)=[O:15]>>[CH3:25][O:24][C:17]1[C:16]([C:14]2[O:15][C:5]3[C:6](=[C:7]([OH:9])[CH:8]=[C:3]([OH:2])[CH:4]=3)[CH:13]=2)=[CH:21][CH:20]=[C:19]([O:22][CH3:23])[N:18]=1

参加物

3

反応物 2

HCID 103833,5-DimethoxyphenolHCID 860961262-Bromo-1-(2,6-dimethoxypyridin-3-yl)ethanone

生成物 1

HCID 545909602-(2,6-Dimethoxypyridin-3-yl)benzofuran-4,6-diol収率 47%

実験手順

This compound was prepared using Method A from 3,5-dimethoxyphenol and 2-bromo-1-(2,6-dimethoxypyridin-3-yl)ethanone: Yield 47% following procedures A.2 and A.5; m.p. 97° C. (dec.); IR 3434, 2958, 1587, 1471, 1319, 1265, 1084, 1020 cm−1; 1H-NMR (500 MHz, δ ppm, DMSO-d6) 9.77 (s, 1H), 9.30 (s, 1H), 8.07 (d, J=8.3 Hz, 1H), 7.13 (s, 1H), 6.51 (d, J=8.3 Hz, 1H), 6.40 (s, 1H), 6.16 (s, 1H), 4.08 (s, 3H), 3.92 (s, 3H); 13C-NMR (126 MHz, δ ppm, CD3OD) 163.3, 159.7, 157.8, 157.5, 152.3, 149.5, 138.2, 113.3, 107.8, 102.8, 102.6, 98.7, 90.7, 54.1, 54.1.

後処理

  1. customThis compound was prepared

出典と根拠

ORDレコード
ord-d154b50fac264ed29cae92f4616688ee
出典データセット
uspto-grants-2014_09
特許番号
US08835659B2

関連ノート

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